In our Indianapolis vs Buffalo prediction for Sunday, November 21, 2021, sports bettors have some choices when wagering on the Bills.

Our Indianapolis Colts vs Baltimore Ravens pick has the home team Ravens at -7.0 (-110). On the other hand, you can find the Colts at +8.5 (-130).

In developing our Indianapolis Colts preview 2021, we noted that this team made the playoffs as a wildcard in 2018 and 2020. Both times they won 11 games.